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Dubois' Lupus Erythematosus & Related Syndromes, 9th ed

著者 : D.J.Wallace & B.H.Hahn (eds.)
出版社 : ELSEVIER
ISBN : 978-0-323-47927-1
ページ数 : 800pp.
出版年 : 2019年

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定価31,889円(本体28,990円 + 税)

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50年以上ものあいだ,臨床で役立つリファレンスとして国際的に評価されるデュボアの改訂第9版.全身性エリテマトーデスおよび関連症候群に関するさまざまな情報を,論理的かつ明瞭に,わかりやすく論じる.今版では,基礎科学の原理から臨床での管理に際した実践的なポイントまでを扱う.全身性エリテマトーデス,結合組織病,および抗リン脂質抗体症候群を包括的に論じたリファレンスを求めるリウマチ専門医および内科医に最適.

SECTION 1 What Is Lupus?
1 History of Lupus
2 Definition and Classification of Lupus and Lupus-Related Disorders
3 The Epidemiology of Lupus

SECTION 2 Pathogenesis
4 Overview of Lupus Pathogenesis
5 Genetics of Human SLE
6 Epigenetics of Lupus
7 The Environment and the Host
8 The Innate Immune System in SLE
9 B Cells and Generation of Antibodies
10 T Cells
11 Adaptive and Innate Immunoregulatory Cells
12 Cytokines in Lupus
13 Immunometabolism
14 Animal Models in Lupus

SECTION 3 Mechanisms of Tissue Injury
15 Abnormalities in Immune Complex Clearance and Apoptotic Cell Clearance
16 The Role of Complement in SLE
17 Apoptosis and Inflammatory Forms of Cell Death
18 Tissue Damage in Lupus: Free Radicals and Fibrosis
19 Pathogenesis of Fibrosis-The Lung as a Model
20 Pathogenesis of Lupus Nephritis
21 Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus
22 Pathogenesis of Cutaneous Lupus
23 Pathogenesis of Neuropsychiatric Lupus
24 Pathogenesis of Antiphospholipid Antibody Syndrome
25 Pathogenesis of Sjögren's

SECTION 4 Autoantibodies
26 Structure and Derivation of Autoantibodies
27 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes
28 Antibodies Against ENA (Sm, RNP, SSA, SSB)
29 Antibodies Against C1q
30 Antilipoprotein and Antiendothelial Cell Antibodies
31 Drug-Induced Lupus Erythematosus

SECTION 5 Clinical Aspects of Lupus Erythematosus
32 Overview and Clinical Presentation
33 Skin Disease in Cutaneous Lupus Erythematosus
34 The Musculoskeletal System and Bone Metabolism
35 Lupus and the Cardiopulmonary System
36 Lupus and the Nervous System: Clinical Aspects, Psychopathology, and Imaging
37 Gastrointestinal and Hepatic Systems
38 Hematologic and Lymphoid Abnormalities in SLE
39 Neonatal Lupus: Pathogenesis and Clinical Approaches
40 Pregnancy and Autoimmune Disease, Reproductive and Hormonal Issues
41 Systemic Lupus Erythematosus in Childhood and Adolescence
42 Clinical Aspects of Antiphospholipid Syndrome
43 Lupus and Infections
44 Ocular, Aural, and Oral Manifestations of Lupus
45 Clinical Aspects of Sjögren's

SECTION 6 Assessment of Lupus
46 Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Clinical Laboratory Tests in Systemic Lupus Erythematosus
47 Differential Diagnosis and Disease Associations
48 Incomplete Lupus, Undifferentiated Connective Tissue Disease, and Mixed Connective Tissue Disease
49 Clinical Markers, Metrics, Indices, and Clinical Trials
50 Lupus Biomarkers

SECTION 7 Management of Lupus
51 Principles of Therapy, Local Measures, and NSAIDs
52 Antimalarial Medications
53 Systemic Glucocorticoid Therapy for SLE
54 Immunosuppressive Drug Therapy
55 Complementary and Alternative Medications, Specialized and Niche Therapies
56 Adjunctive Treatments and Preventive Measures
57 Targeted Therapies in SLE
58 Management of Cutaneous Lupus Erythematosus
59 Epidemiology and Management of Lupus Nephritis
60 Management of Sjögren's

SECTION 8 Outcomes
61 Socioeconomic and Disability Aspects
62 Prognosis and Mortality of SLE

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