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Targeted Radionuclide Therapy

’˜ŽÒ : T.W.Speer
o”ÅŽÐ : LIPPINCOTT WILLIAMS & WILKINS
ISBN : 978-0-7817-9693-4
ƒy[ƒW” : 537pp.(110illus.)
o”Å”N : 2011”N

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’艿23,965‰~(–{‘Ì22,190‰~ { Å)

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Table of Contents
Part 1: IMMUNOLOGY AND TARGETING CONSTRUCTS

The Immune System / Methods for Development of Monoclonal Antibody Therapeutics / Peptides / Affibody Molecules for Targeted Radionuclide Therapy / Aptamers
Part 2: PHYSICS AND RADIOBIOLOGY OF TRT
The Physics and Radiobiology of TRT / Chelation Chemistry / Radiation Dosimetry / Microdosimetry / Radiation Safety for RT
Part 3: TUMOR MICROENVIRONMENT AND DELIVERY STRATEGIES
Employing SEREX / Antibody Penetration into Tumors / Overcoming Barriers Posed by Solid Tumors / The Delivery Construct / The Type of Radionuclide / Pretargeting Strategies for TRT / Combined Modality Strategies / Extracorporeal Techniques / Concept of Systemic Therapy / Modeling of the Systemic Cure with TRT
Part 4: UNCONJUGATED THERAPY
Thyroid Cancer / Unconjugated Radiopharmaceuticals / 90-y Microspheres / SIRT
Part 5: CONJUGATED THERAPY
Colorectal Cancer / Pancreatic Cancer / Hepatobillary Cancer / Astrocytoma / Medullary Thyroid Cancer / Head and Neck Cancer / Prostate Cancer / Renal Cell Carcinoma / Bladder Cancer / Leukemia / Non-Hodgkin's Lymphoma / Hodgkin's Disease / Multiple Myeloma / Neuroendocrine Tumors / Malignancies Treated with Peptides / Ovarian Cancer / Osteosarcoma / Pediatric Tumors / Palliation / Melanoma