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Clinical Pharmacokinetics & Pharmacodynamics, 4th ed.

- Concepts & Applications

’˜ŽÒ : M.Rowland & T.N.Tozer (eds.)
o”ÅŽÐ : LIPPINCOTT WILLIAMS & WILKINS
ISBN : 978-0-7817-5009-7
ƒy[ƒW” : 839pp.(470illus.)
o”Å”N : 2011”N

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Table of Contents
Non-Proprietary and Brand Names of Drugs in Text and Illustrations
Definition of Symbols

I. Basic Considerations
1. Therapeutic Relevance
2. Fundamental Concepts and Terminology
II. Exposure and Response after a Single Dose
3. Kinetics Following an Intravenous Bolus Dose
4. Membranes and Distribution
5. Elimination
6. Kinetics Following an Extravascular Dose
7. Absorption
8. Response Following a Single Dose
III. Therapeutic Regimens
9. Therapeutic Window
10. Constant-Rate Input
11. Multiple Dose Regimens
IV. Individualization
12.Variability
13.Genetics
14. Age, Weight, and Gender
15. Disease
16. Nonlinearities
17. Drug Interactions
18. Initiating and Managing Therapy
V. Supplemental Topics
19. Distribution Kinetics
20. Metabolites and Drug Response
21. Protein Drugs@New!
22. Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data@New!
Appendices
A. Assessment of AUC
B. Ionization and the pH Partition Hypothesis
C. Distribution of Drugs Extensively Bound to Plasma Proteins
D. Plasma-to-Blood Concentration Ratio
E. Well-stirred Model of Hepatic Clearance
F. Absorption Kinetics
G. Wagner-Nelson Method
H. Mean Residence Time
I. Amount of Drug in Body on Accumulation to Plateau
J. Answers to Study Problems