Treatment of Melanoma

This book provides an overview of melanoma skin cancer and illustrates the most recent advances in the field of its clinical management. Today, thanks to new treatments like targeted therapies and immunotherapies, about 50% of metastatic patients can be cured and healed. Moreover, recently, such treatments have proven effective in the adjuvant setting by reducing the risk of disease progression and the mortality rate by 30-40%. Melanoma management represents a model for immuno-oncology, and starting from the experiences made in this field, today immune checkpoint inhibitors can also be successfully used to treat other neoplasms. However, in spite of the good results achieved, mortality rates are still high. For this reason, we still need to gain a better understanding of the mechanisms underlying primary and acquired resistance, and to find ways to extend the long-term benefits that have been recently achieved in resistant patients.